enjaga oba enjaga kye kimu ku bikozesebwa ebisinga

okwettanirwa mu

nsi yonna naddala mu bavubuka

wadde nga specifics of cannabis

engeri ze ez’omuze zikyakubaganyizibwako

ebirowoozo nnyo

obuzibu bw’okwesigamira ku njaga buteekeddwa mu butongole mu

dsm-5 era okumala ebbanga eddene okukozesa ennyo

kulaze nti kuleeta abamu level of dependency

enjaga eva mu bimuli

by’ebimera by’enjaga sativa ebirimu amafuta

agalimu obuzito bwa molekyu entonotono ezitabulwa mu masavu

eziyitibwa

cannabinoids cannabinoids enkulu essatu

tetrahydrocannabinol era eyitibwa THC

cannabidiol era eyitibwa CBD ne

cannabinoid era eyitibwa cbn buli emu

ekwatagana n’ebikolwa eby’enjawulo ebikola ku bwongo

for okugeza THC ekwatagana

n’enjaga ey’okwesanyusaamu ey’omutindo ogwa waggulu

era efulumya ebikolwa nga euphoria

analgesia mild hallucinations

n’okweyongera kw’okwagala cannabidiol ku

ludda olulala terina

bikolwa bya psychoactive era etera okuteekebwa mu

njaga ey’obujjanjabi kubanga erina

eby’enjawulo effects omuli okubeera

analgesic anti-inflammatory anti-seizure

appetite stimulating and anxiety

reducing okutegeera engeri enjaga

gy’ekola ka zoom mu synapse

y’obwongo okulaba engeri stimulus response gye

induced generally awatali ddagala

normally electrical signals oba action

potentials travel down the axon to ekitundu kya

axon ekivaako okufulumya

ababaka ba kemiko abayitibwa

obusimu obuyitibwa neurotransmitters okuva mu buwuka obuyitibwa synaptic vesicles

mu synapse obusimu obutambula

butambula okuyita mu synapse ne bwesiba ku

receptors ku postsynaptic neuron

gye buwa obutoffaali obubaka oluvannyuma

lw’obusimu obwo okukola

omulimu gwabwo bwe busumulula okuva mu bikwata era

asobola okumala okusaasaana wala get degraded by

enzymes oba get picked up by proteins and

return to the release site in a process

called reuptake when can

is consumed ebirungo bya cannabinoid

ebirimu bisiba a cannabinoid receptors

ezisangibwa mu

busimu obw’omu makkati n’obw’okumpi nga nga bwe kiri ne

typ ezimu es of cells like immune cells

these receptors are normally stimulated

by endogenous cannabinoids also called

endocannabinoids ekyokulabirako eky’ensi entuufu

ye phenomenon y’omuddusi eya waggulu nga muno

endocannabinoid ezibeerawo mu butonde

eziyitibwa anand ahmad zifuluma mu kiseera

ky’okukola dduyiro ow’amaanyi ekifuula omuddusi

okuwulira obutabeera na kweraliikirira mu ngeri gye kiri kikola kiri

nti anand amide efulumizibwa okuva mu post

synaptic dendrites era

esaasaanya amakulu ag’emabega okudda emabega okutuuka ku

presynaptic terminal gye yeesiba

ku cannabinoid receptor mu kifo ekyo

waliwo enkyukakyuka mu butoffaali

ezisembayo okukola enkyukakyuka mu kutambula kwa

calcium ne potassium okuyita mu

presynaptic cell membrane ekiziyiza

depolarization kale presynaptic nerve

terminals zikoma okufulumya

neurotransmitters nga gaba ne

glutamate ekikendeeza neuronal

excitability enkola eyitibwa

presynaptic inhibition mu bufunze ne

ne amide okuva mu postsynaptic neuron

basically pumps the brakes on

neurotransmitter release fr om the

presynaptic neuron era ekivaamu kwe

kuwulira okukkakkamu kubanga THC erina

ensengekera y’eddagala efaananako n’enkomerero

amide yagatta a cannabinoid

receptors n’okulimba omubiri

okuvaamu okuwulira okufaananako –

omulimu omuzibu ogw’okudduka okuzibu mu butuufu

cannabinoids ziyitiridde lipophilic

ekitegeeza nti zisobola bulungi okuyingira mu

busimu obw’omu makkati n’obw’okumpi

era zisobola okusitula ebikwata okumala

ekiseera ekiwanvu ennyo okusinga endocannabinoids nga

zikola ekikolwa ekiwanvu kati waliwo

ebika bibiri eby’ebikwata ku canopy

cannabinoid receptor type 1

mu cannabinoid receptor type 1

esinga kusangibwa mu central

enkola y’obusimu era nga ekuŋŋaanidde nnyo mu

bitundu nga cerebral cortex

cerebellum hippocampus basal ganglia

hypothalamus mu spinal cord cannon banal

esiba ku cannabinoid receptor type 1

okukendeeza ku mirimu mu bitundu

ebyo eby’obwongo ekivaamu

okulowooza okutono okukendeera ku situleesi okukosa

okuyiga n’okujjukira okukyusa entambula

n’okukwasaganya kwongedde app etite ne

analgesia activation of the cannabinoid

receptor type 1 era activates the

body’s endogenous opioid system

releasing dopamine into the nucleus

accumbens okuvaamu enneewulira

z’essanyu n’empeera ekinnyonnyola

lwaki ekkubo liyinza okuba ery’omuze mu njawulo

cannabinoid receptor type 2 esangibwa ku

butoffaali bw’abaserikale b’omubiri mu bitundu by’obusimu obw’okumpi

cannabidiol yeegatta ku

cannabinoid receptor type 2 okuziyiza

emirimu gyazo mu kukola

anti-inflammatory and vapetvlive vape analgesic effects

THC ku ludda olulala esobola okwegatta ku byombi

cannabinoid receptor type 1 ne

cannabinoid receptor type 2 era

n’olwekyo erina ebikolwa eby’enjawulo

kati the pharmacokinetics of cannabis

yawukana okusinziira ku oba

enjaga efuuwa oba enywa mu kamwa

abasinga obungi ku bakozesa eby’okwesanyusaamu bafuuwa

enjaga nga bayita mu sigala ayiringisibwa ayitibwa

joints nga kwotadde ne mu payipu oba ne

vaporizers enjaga eri mu kiwanga

erimu ekirungo ekiyitibwa

tetrahydrocannabinol ik acid

ekilina okuba okubuguma okufuuka p sychoactive

THC enkola y’okubuguma mu butuufu esaanyawo

nga 1/3 ku THC n’ebirala bibula

n’okufulumya omukka mu mukka ogw’oku mabbali

nga guno gwe mukka ogufuluma okuva ku

nkomerero ya sigala oba payipu kale

akatundu kokka ke kayingizibwa ne kayingizibwa

mu mawuggwe agayingizibwa THC eva mu

mawuggwe n’egenda mu musaayi n’eyingira

mu masavu g’obwongo n’omubiri

gye gasobola okukuŋŋaanyizibwa y’ensonga lwaki

ebiva mu kunywa enjaga bisobola okuwulirwa

mu ddakiika ntono era bisobola okumala essaawa eziwera

edibles ku ludda olulala bye

bikozesebwa ebikozesebwa ebirimu enjaga era

era zirina okubuguma okukyusa

tetrahydrocannabinol ik acid okufuuka

THC ekola ku by’omwoyo omuntu

bw’alya enzymes ezigaaya emmere ezitaliibwa

zimenyaamenya THC ezisinga obungi n’alekawo

ekitundu kyokka ekya THC

okuyingira mu musaayi omusaayi okuva

mu nkola y’olubuto gufuna

etuusibwa mu kibumba THC gy’efuna

metabolized era kivaako

okutondebwawo kwa hydroxy Delta 9 THC kkumi n’emu

kino is a psychoactive metabolite even

more potent than THC kubanga esobola

bulungi okuyingira mu kiziyiza ky’omusaayi n’obwongo

kino okusinga kinnyonnyola lwaki abantu ssekinnoomu

abanywa enjaga okusinga

okugifuuwa bafuna obubonero obw’amaanyi ennyo

obw’omutwe

all right let’s step back for a second

and say that you’. re at rest without

anything stimulating your reward pathway

in this situation obwongo bwo bukuuma

omutima gwo okukuba puleesa

n’okuzuukuka mu mbeera eyabulijjo eyitibwa

homeostasis kati katugambe nti mukama wo

akuweereza obubaka all of a sudden

oyinza okuwulira ng’otuuyana n’okumyuuka era your

omutima guyinza okubuuka katono kati oli

waggulu w’omutindo gwo ogwa bulijjo ogwa homeostasis

kubanga ekintu kikyuse bulungi naye

tekisigala bwe kityo okumala ebbanga ddene era

oluvannyuma lw’obutonde Brian azza ebintu

wansi ku baseline n’okuddiŋŋana enjaga

okukozesa ebintu bitono okutandika kibeerawo

katugambe nti onywa sigala oba okugimira mu

kiseera ekigere n’okugiteeka nga ku mbalaza ku

ssaawa 6:00 ez’ekiro. oluvannyuma lw’okulya ekyeggulo olwo otandika

okuwulira ng’otulo otulo katono naye era

okyalina enjala mpozzi n’okweraliikirira katono

ku mulimu oba essomero enkya kale

n’okwata akamere akamaze okulya ekyeggulo tune in to a

TV show and zone out until you fall

asleep now your obwongo bukwata ku

nkola eyo omulundi oguddako ku ssaawa 6:00 ez’ekiro. ku

mbalaza obwongo bwo bukujjukiza

obudde obulungi bwe wafuna ekiro ekikeesezza olwaleero ng’olya chips

n’okulaba Netflix mu buliri ng’oli

waggulu ekikuleetera okwagala okuddamu okubikola

byonna kati katugambe nti oli ssaawa 6 p.m.

after dinner porch time rolls around naye

tolina cannabis yonna mu

mbeera eyo okyalina okweraliikirira ku

mirimu enkya naye tolina

cannabis ekuwugula nokuwulira nga okooye

nga tosobola kwebaka owulira nga

onyiize nomaliriza okuwulira n’okweraliikirira

okusinga bwe wakola ekiro ekibiri ekiyise

bwe wasobola okunywa sigala ng’olekera awo

okukozesa enjaga oyinza okufuna

obubonero obutono obw’okuggwaamu sigala

ng’okwegomba okunyiiga okweraliikirira n’okukaluubirirwa

okwebaka obubonero buno wadde nga

tebutta kubanga waliwo

ebikwata cannabinoid bitono nnyo mu the brain stem

so respiration and vital signs are

unaffected by cannabis use naye biyinza

okuba pretty uncomfortable obutabeera bulungi

n’okwegomba kuyinza okukuleetera okwagala okuddamu okunywa

sigala ne kukuleetera okukulaakulanya

enkola eyo ey’okukozesa obuzibu okwetongola

abatiini balina akabi ak’amaanyi naddala

ak’okukulaakulanya okwesigama ku njaga

kubanga ebifo eby’empeera eby’obwongo obukula

bisinga kukwata ku

bikolwa eby’empeera eby’enjaga r emember

neurons that fire together wire together

abantu abakozesa enjaga ennyo okuva mu

myaka emito bajja kumaliriza nga balina

amakubo ag’enjawulo ag’empeera okusinga abo abatalina

buzibu bakozesa enjaga independents

bamanyiddwa olw’empisa nga

okunywa sigala emirundi mingi oba okumala ekiseera ekiwanvu okusinga bwe

wali ogenderera obutasobola okusala ku

kumala ebiseera ebisukkiridde nga onoonya oba

okukozesa eddagala lino n’okwegomba enjaga naawe

oyinza okuba n’ekizibu singa okukozesa kwo

kukosa bubi obusobozi bwo okukola

genda ku ssomero sigala nga oli mutebenkevu mu mubiri oba

okuba n’obulamu obulungi obw’awaka n’enkolagana ennungi

naddala singa ogenda mu

maaso n’okukozesa wadde okubeera n‟ebizibu ebyo ku

nkomerero oyinza okuba nga weesigama ku

njaga singa ofuna okugumiikiriza

ebivaamu era nga weetaaga ebisingawo okuwulira waggulu oba singa

ofuna obubonero bw‟okuggwaamu

enjaga ey‟amaanyi ebadde

ekwatagana n‟okukula kw‟

okweraliikirira n‟okwennyamira awamu

n‟obuzibu bw‟omutwe nga schizophrenia

it kizibu wadde okuteekawo

causality era nga nayo p ossible nti

abantu ssekinnoomu edda predisposed to

mental health problems mpozzi okukozesa

enjaga okwejjanjaba

okunoonyereza ku long-term physical

effects of cannabis nakyo kigenda mu maaso era

kirabika waliwo akakwate wakati

w’okunywa enjaga ne hyper-inflated

lungs chronic bronchitis

n’obulabe obweyongedde of respiratory infections

like pneumonia as well as a tentative

association with heart attacks and

strokes okwesigamira ku njaga okusinga

essira liteekeddwa ku kukendeeza ku nkozesa emirundi mingi nga bayita

mu kugatta eddagala

n’okujjanjaba eddagala erimu eriyamba ku

bubonero bw’okuggwaamu enjaga ng’eddagala

eriweweeza ku kweraliikirira eriyitibwa buspirone

okusinga obujjanjabi bw‟enneeyisa buzingiramu obujjanjabi

obw‟omutwe obw‟omuntu ku bubwe oba

pulogulaamu z‟ekibiina enkola emu entongole

eyitibwa okubuulirira okukubiriza nga eno ye

ngeri y‟okubuulirira egenderera ekiruubirirwa

eyamba abantu ssekinnoomu okunoonyereza n‟okugonjoola obutategeeragana

bwabwe ku nneeyisa

alright nga okuddamu okw‟amangu THC mu

njaga ekoppa ebibaawo mu butonde

e ndocannabinoid neurotransmitters era

kitondekawo okunyweza okulungi okw’okukozesa

okuyita mu nneewulira z’essanyu

n’okunyweza okubi okukozesa okuyita mu

bubonero bw’okuggwaamu nga okukozesa

kuyimiriziddwa okukozesa okw’ekiseera ekiwanvu kuyinza mu mbeera ezitali nnyingi

okuleeta okwesigama nga kino kwe kwesigama

ku njaga oba THC okukola mu ngeri

eya bulijjo ekisinga okukola obulungi obujjanjabi

buzingiramu obujjanjabi bw’empisa n’okwagala kungi

n’obuwagizi okuva mu famire n’emikwano

webale kulaba bw’oba oyagala

okubuuka mu buziba ku mulamwa guno

laba nga Moses org gye tulina

ebibuuzo bya flashcards n’ebikozesebwa ebirala eby’entiisa

okukuyamba okuyiga eddagala

si ekyo bulijjo osobola okutuwagira nga

owaayo ku patreon nga owandiika ku

mukutu gwaffe oba okutugoberera ku social media

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